Endothelial-to-Mesenchymal Transition Contributes to Accelerated Atherosclerosis in Hutchinson-Gilford Progeria Syndrome
Progerin-induced VSMC alterations promote EC dysfunction and EndMT through TGFβ1/SMAD3, identifying this process as a candidate target for Hutchinson-Gilford progeria syndrome treatment. These findings also provide insight into the complex role of EndMT during atherogenesis.
Authors
- Carlos Torroja (ORCID: https://orcid.org/0000-0001-8914-3400)
- Jacob Fog Bentzon (ORCID: https://orcid.org/0000-0002-3020-5002)
- Paula Nogales (ORCID: https://orcid.org/0000-0002-6965-6724)
- Fátima Sánchez‐Cabo (ORCID: https://orcid.org/0000-0003-1881-1664)
- Rosa M. Nevado (ORCID: https://orcid.org/0000-0003-2341-3652)
- Vı́ctor Quesada (ORCID: https://orcid.org/0000-0002-8398-3457)
- Ana Dopazo (ORCID: https://orcid.org/0000-0002-4910-1684)
- Magda R. Hamczyk (ORCID: https://orcid.org/0000-0003-2198-7353)
- Vicente Andrés (ORCID: https://orcid.org/0000-0002-0125-7209)
- Aránzazu Rosado (ORCID: https://orcid.org/0000-0002-3362-2450)
- Pilar Gonzalo (ORCID: https://orcid.org/0000-0001-8811-8369)
- María J. Andrés‐Manzano (ORCID: https://orcid.org/0009-0002-1202-5478)
- Carlos López-Otı́n (ORCID: https://orcid.org/0000-0001-6964-1904)
Institutions
- Inserm (FR)
- Universidad de Oviedo (ES)
- Aarhus University (DK)
- Université Paris Cité (FR)
- Aarhus University Hospital (DK)
- Universidad Nebrija (ES)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Centro de Investigación Biomédica en Red (ES)
- Anna Needs Neuroblastoma Answers (US)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Circulation
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1161/circulationaha.123.065768
- Citations
- 23
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 5.38
Funders
- Centro Nacional de Investigaciones Cardiovasculares