MARVEL-minimising the emergence and dissemination of HIV-1 drug resistance in Portuguese-speaking African Countries (PALOP): low-cost portable NGS platform for HIV-1 surveillance in Africa

The implementation of this low-cost NGS platform for HIV-1 surveillance in the PALOP will allow: (i) to increase DRM surveillance capacity in resource-limited settings; (ii) to understand the pattern and determinants of dissemination of resistant HIV-1 strains; and (iii) to promote the development of technical and scientific skills of African researchers for genomic surveillance of viral pathogens and bioinformatics analysis. These objectives will contribute to reinforcing the capacity to combat HIV infection in Africa by optimizing the selection of ART regimens, improving viral suppression, and reducing ADR or TDR prevalence in PALOPs, with relevant implications for public health.

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Publication Details

Journal
BMC Infectious Diseases
Published
2024-08-29
DOI
https://doi.org/10.1186/s12879-024-09803-1
Citations
5
Primary Topic
HIV/AIDS Research and Interventions
Type
article
Field-Weighted Citation Impact
1.95
Controls
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article

MARVEL-minimising the emergence and dissemination of HIV-1 drug resistance in Portuguese-speaking African Countries (PALOP): low-cost portable NGS platform for HIV-1 surveillance in Africa

Perpétua Gómes, Tacilta Nhampossa, Isabel Inês Araújo, Cruz S. Sebastião et al.
5 citations
BMC Infectious Diseases
HIV/AIDS Research and Interventions
1.95
article

MARVEL-minimising the emergence and dissemination of HIV-1 drug resistance in Portuguese-speaking African Countries (PALOP): low-cost portable NGS platform for HIV-1 surveillance in Africa

Perpétua Gómes, Tacilta Nhampossa, Isabel Inês Araújo, Cruz S. Sebastião, Silvânia da Veiga Leal, Mafalda Miranda, Victor Pimentel, Ana Abecasis, Maria do Rosário Oliveira Martins, Marta Pingarilho, Jamila Bathy, Katia Toancha, Elizângela Bonfim, Lazismino Lázaro
article en
5 citations

Abstract

The implementation of this low-cost NGS platform for HIV-1 surveillance in the PALOP will allow: (i) to increase DRM surveillance capacity in resource-limited settings; (ii) to understand the pattern and determinants of dissemination of resistant HIV-1 strains; and (iii) to promote the development of technical and scientific skills of African researchers for genomic surveillance of viral pathogens and bioinformatics analysis. These objectives will contribute to reinforcing the capacity to combat HIV infection in Africa by optimizing the selection of ART regimens, improving viral suppression, and reducing ADR or TDR prevalence in PALOPs, with relevant implications for public health.

BMC Infectious DiseasesVol. 24(1)
University of Cape Verde (CV), Escola Superior de Saúde Egas Moniz (PT), Centro Nacional de Endemias (ST), Manhiça Health Research Centre (MZ), Universidade Nova de Lisboa (PT)
Good health and well-being
Openalex Percentile: Top 14%
HIV/AIDS Research and Interventions
1.95
DOIOpen Access PDFOpenAlex
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