Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction
KI is associated with adverse outcomes in HFpEF independent of baseline eGFR. Patients with HFpEF and KI exhibit a plasma proteomic signature indicative of complement activation, inflammation, fibrosis, and impaired cholesterol homeostasis.
Authors
- Julio A. Chirinos (ORCID: https://orcid.org/0000-0001-9035-5670)
- Ali Javaheri (ORCID: https://orcid.org/0000-0001-6657-331X)
- Oday Salman (ORCID: https://orcid.org/0000-0002-8390-1036)
- Bianca Pourmussa (ORCID: https://orcid.org/0000-0003-4763-795X)
- Marie‐Joe Dib (ORCID: https://orcid.org/0000-0001-7591-5684)
- Ernst R. Rietzschel (ORCID: https://orcid.org/0000-0002-8422-177X)
- Dietmar Seiffert (ORCID: https://orcid.org/0009-0006-4818-2407)
- Francisco Ramírez‐Valle (ORCID: https://orcid.org/0000-0002-8625-5869)
- Joe David Azzo (ORCID: https://orcid.org/0009-0000-8161-9611)
- Thomas P. Cappola (ORCID: https://orcid.org/0000-0002-9630-7204)
- Mark Richards (ORCID: https://orcid.org/0000-0002-2023-8177)
- Joseph Gogain (ORCID: https://orcid.org/0000-0001-7748-4822)
- Karl Kammerhoff (ORCID: https://orcid.org/0009-0007-5066-391X)
- Robert Neil Doughty (ORCID: https://orcid.org/0000-0002-3503-1689)
- Jaclyn Dennis
- David A. Gordon (ORCID: https://orcid.org/0000-0001-9882-8372)
- Douglas L. Mann (ORCID: https://orcid.org/0000-0002-2516-0145)
- Vanessa P. M. van Empel (ORCID: https://orcid.org/0000-0002-6864-0296)
- Christina Ebert (ORCID: https://orcid.org/0000-0003-0985-3547)
- Joseph Maranville (ORCID: https://orcid.org/0000-0002-1688-1573)
- Jordana B. Cohen (ORCID: https://orcid.org/0000-0003-4649-079X)
- Lei Zhao (ORCID: https://orcid.org/0000-0001-7099-3712)
- Zhaoqing Wang (ORCID: https://orcid.org/0000-0003-1515-4945)
- Peter Schäfer (ORCID: https://orcid.org/0000-0002-3880-0850)
- Manyun Zhao
- Sushrima Gan (ORCID: https://orcid.org/0000-0002-0221-9925)
Institutions
- University of Auckland (NZ)
- Bristol-Myers Squibb (Germany) (DE)
- National University of Singapore (SG)
- Washington University in St. Louis (US)
- Hospital of the University of Pennsylvania (US)
- Ghent University Hospital (BE)
- University Medical Center (US)
- Maastricht University (NL)
- Bristol-Myers Squibb (United States) (US)
- SomaLogic (United States) (US)
- National University Heart Centre Singapore (SG)
- University of Pennsylvania (US)
- University of Otago (NZ)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1161/jaha.123.033660
- Citations
- 3
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.02