Splicing Factor PTBP1 Silencing Induces Apoptosis of Human Cervical Cancer Cells via PI3K/AKT Pathway and Autophagy
Overall, PTBP1 silencing can induce cervical cancer cells apoptosis mainly through PI3K/AKT pathway and protective autophagy. This study provides preliminary evidence for PTBP1 as a therapeutic target or prognostic marker for cervical cancer.
Authors
- Yang Sun (ORCID: https://orcid.org/0000-0003-3271-1491)
- Yun Zhou (ORCID: https://orcid.org/0009-0004-6264-4917)
- Haizhou Ji (ORCID: https://orcid.org/0000-0003-2936-9488)
- Qinying Liu (ORCID: https://orcid.org/0000-0002-1667-1111)
- Tongyu Liu (ORCID: https://orcid.org/0000-0002-8579-2144)
- Dan Hu (ORCID: https://orcid.org/0000-0003-2911-9788)
- Rongfang Huang
- Lijun Chen
- Yuzhen Lin
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-08-19
- DOI
- https://doi.org/10.31083/j.fbl2908289
- Citations
- 4
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province