Bioinformatic Analysis Reveals Bone Marrow Kinase as a Potential Diagnostic and Prognostic Biomarker for Multiple Cancer Types
Our study revealed BMX as a diagnostic biomarker in BRCA, COAD, LUAD, LUSC, and READ and a prognostic biomarker in KIRC, LIHC, SARC, and UCEC. Furthermore, epigenetic variables may have a greater impact on BMX expression levels especially in LUAD and LUSC. This study also emphasized the role of BMX in the infiltration of immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, in certain cancers. The BMX expression level highlights the prognostic value and potential therapeutic potential of BMX.
Authors
- Marwa F. Alamin
- Mohamed Alfaki (ORCID: https://orcid.org/0000-0003-4913-2357)
- Lubna S. Elnour
- Rihab Mohammed
- Amna Makawi
- Somia A Khalafallah
- Ethar A Eltayeb Ahmed
- Aml K Mohamed
- À. Balla
Institutions
- University of Khartoum (SD)
- Dalian Medical University (CN)
- International University of Africa (SD)
- Sidra Medical and Research Center (QA)
- University of Bahri (SD)
- Ibn Sina Hospital (KW)
- National Defence University of Malaysia (MY)
Publication Details
- Journal
- Cureus
- Published
- 2024-08-29
- DOI
- https://doi.org/10.7759/cureus.68093
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.29