Bioinformatic Analysis Reveals Bone Marrow Kinase as a Potential Diagnostic and Prognostic Biomarker for Multiple Cancer Types

Our study revealed BMX as a diagnostic biomarker in BRCA, COAD, LUAD, LUSC, and READ and a prognostic biomarker in KIRC, LIHC, SARC, and UCEC. Furthermore, epigenetic variables may have a greater impact on BMX expression levels especially in LUAD and LUSC. This study also emphasized the role of BMX in the infiltration of immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, in certain cancers. The BMX expression level highlights the prognostic value and potential therapeutic potential of BMX.

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Publication Details

Journal
Cureus
Published
2024-08-29
DOI
https://doi.org/10.7759/cureus.68093
Citations
1
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
0.29
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Bioinformatic Analysis Reveals Bone Marrow Kinase as a Potential Diagnostic and Prognostic Biomarker for Multiple Cancer Types

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Bioinformatic Analysis Reveals Bone Marrow Kinase as a Potential Diagnostic and Prognostic Biomarker for Multiple Cancer Types

Marwa F. Alamin, Mohamed Alfaki, Lubna S. Elnour, Rihab Mohammed, Amna Makawi, Somia A Khalafallah, Ethar A Eltayeb Ahmed, Aml K Mohamed, À. Balla
article en
1 citations

Abstract

Our study revealed BMX as a diagnostic biomarker in BRCA, COAD, LUAD, LUSC, and READ and a prognostic biomarker in KIRC, LIHC, SARC, and UCEC. Furthermore, epigenetic variables may have a greater impact on BMX expression levels especially in LUAD and LUSC. This study also emphasized the role of BMX in the infiltration of immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, in certain cancers. The BMX expression level highlights the prognostic value and potential therapeutic potential of BMX.

CureusVol. 16(8)
University of Khartoum (SD), Dalian Medical University (CN), International University of Africa (SD), Sidra Medical and Research Center (QA), University of Bahri (SD), Ibn Sina Hospital (KW), National Defence University of Malaysia (MY)
Zero hunger
Openalex Percentile: Top 40%
Cancer Genomics and Diagnostics
0.29
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