OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression
Collectively, the OTUB2/SP1/GINS1 axis played a pivotal role in driving stemness feature, chemoresistance, and EMT in colon cancer. These results shed new light on understanding chemoresistance and metastasis mechanisms involved in colon cancer.
Authors
- Shimin Zhao (ORCID: https://orcid.org/0000-0002-3674-9107)
- Wenjie Zhu (ORCID: https://orcid.org/0000-0002-2255-240X)
- Zitao Liu (ORCID: https://orcid.org/0000-0003-0491-307X)
- Jun Huang
- Changlei Wu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s12964-024-01789-2
- Citations
- 8
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China