Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
Our preclinical study identifies WEE1-mediated replication stress tolerance as molecular vulnerability in FUS::DDIT3-driven MLS tumorigenesis that could represent a novel target for therapeutic intervention.
Authors
- Stefan Fröhling (ORCID: https://orcid.org/0000-0001-7907-4595)
- Wolfgang Hartmann (ORCID: https://orcid.org/0000-0002-7609-5021)
- Claudia Rössig (ORCID: https://orcid.org/0000-0002-8672-5285)
- Kwang Seok Lee (ORCID: https://orcid.org/0000-0001-7682-5736)
- Bianca Altvater (ORCID: https://orcid.org/0000-0003-4936-4879)
- Pierre Åman (ORCID: https://orcid.org/0000-0002-1482-8875)
- Marcel Trautmann (ORCID: https://orcid.org/0000-0002-5842-1196)
- Susanne Häfner (ORCID: https://orcid.org/0000-0003-0663-8382)
- Claudia Scholl (ORCID: https://orcid.org/0000-0001-6768-322X)
- Eva Wardelmann (ORCID: https://orcid.org/0000-0001-6788-4910)
- Ilka Isfort (ORCID: https://orcid.org/0000-0002-7485-8769)
- Ruth Berthold (ORCID: https://orcid.org/0000-0001-7918-1657)
- Anna Kuntze (ORCID: https://orcid.org/0009-0004-0145-6111)
- Svenja Wosnig
- Lorena Heinst (ORCID: https://orcid.org/0000-0002-6855-2982)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Sahlgrenska University Hospital (SE)
- University Hospital Heidelberg (DE)
- University Hospital Münster (DE)
- National Center for Tumor Diseases (DE)
- Institute of Human Genetics (PL)
- University Hospital Ulm (DE)
- FH Münster University of Applied Sciences (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1152
- Citations
- 1
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe