Effects of BRCA variation on prognosis in patients with nonmetastatic breast cancer
Patients with BRCA1 variation had more aggressive tumor characteristics, such as higher Ki67 and higher grade. Also, triple-negative breast cancer was more common. The presence of BRCA1 variation may worsen survival outcomes. Neoadjuvant treatment responses of patients with BRCA variations were significantly better, and neoadjuvant treatment may contribute to survival outcomes in nonmetastatic patients with BRCA variations.
Authors
- Berna Çakmak Öksüzoğlu (ORCID: https://orcid.org/0000-0002-2756-8646)
- Haktan Bağış Erdem (ORCID: https://orcid.org/0000-0002-4391-1387)
- Öztürk Ateş (ORCID: https://orcid.org/0000-0003-0182-3933)
- Alper Türkel (ORCID: https://orcid.org/0000-0001-5071-9679)
- Taha Bahsi (ORCID: https://orcid.org/0000-0001-7210-7374)
- Cengiz Karaçin (ORCID: https://orcid.org/0000-0002-7310-9328)
- Hicran Anık (ORCID: https://orcid.org/0009-0001-7992-4008)
- İlknur Deliktaş Onur (ORCID: https://orcid.org/0000-0001-9884-5789)
- İrem Öner (ORCID: https://orcid.org/0000-0001-9486-6187)
- Özge Özalp
Institutions
- Memorial Ankara Hospital (TR)
- Ankara Onkoloji Eğitim ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- Annals of Human Genetics
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1111/ahg.12577
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00