The Exploratory Study of the PTEN-AKT/mTOR Signaling Pathway in the Corresponding Dorsal Root Ganglion during Compensatory Repair via Small Gap Amplification in Sciatic Nerve Injury
Compensatory repair of sciatic nerve transection injury using a chitin cannula for small gap anastomosis via sleeve jointing can restore the morphology and function of the sciatic nerve, effector muscles, and corresponding dorsal root ganglia by activating the PTEN-AKT/mTOR signaling pathway in the dorsal root ganglia. Our findings provide novel therapeutic targets for peripheral nerve injuries.
Authors
- Hui Zeng (ORCID: https://orcid.org/0000-0002-7456-6061)
- Yuhui Kou (ORCID: https://orcid.org/0000-0003-1523-825X)
- Tiantian Qi (ORCID: https://orcid.org/0000-0002-7521-9168)
- Jian Weng (ORCID: https://orcid.org/0000-0001-9262-4993)
- Fei Yu (ORCID: https://orcid.org/0000-0002-6886-1312)
- Tianbing Wang (ORCID: https://orcid.org/0000-0002-5431-0931)
- Yusong Yuan (ORCID: https://orcid.org/0009-0003-6601-6363)
Institutions
- Shenzhen University (CN)
- Peking University (CN)
- Peking University People's Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-08-21
- DOI
- https://doi.org/10.31083/j.jin2308157
- Citations
- 4
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province