METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination
METTL14 inhibited ferroptosis to ameliorate AD pathological development by m6A modification of <i>TUG1</i> to activate GDF15/NRF2 axis, providing a novel therapeutic target for AD.
Authors
- Yangbo Zhang (ORCID: https://orcid.org/0000-0001-8213-9062)
- Zhijuan Cheng (ORCID: https://orcid.org/0000-0001-9823-9375)
- Xunhu Gu
- Jun Min (ORCID: https://orcid.org/0000-0001-6380-3351)
- Yuanqing Song
- Xu Liu
Institutions
- Nanchang University (CN)
- Jiujiang First People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-08-21
- DOI
- https://doi.org/10.31083/j.fbl2908298
- Citations
- 19
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- National Natural Science Foundation of China