Physiologically based pharmacokinetic models for predicting lamotrigine exposure and dose optimization in pediatric patients receiving combination therapy with carbamazepine or valproic acid
We have successfully developed PBPK models and DDI models for LTG in adults and children, which provide a reference for rational drug use in the pediatric population.
Authors
- Wenxin Shao (ORCID: https://orcid.org/0009-0006-5120-0303)
- Zhiwei Liu (ORCID: https://orcid.org/0009-0005-2924-2622)
- Kuo Geng (ORCID: https://orcid.org/0009-0002-6343-8619)
- Xingwen Wang (ORCID: https://orcid.org/0000-0001-9386-3208)
- Yiming Li (ORCID: https://orcid.org/0009-0007-6422-1442)
- Haitang Xie
- Wenhui Wang (ORCID: https://orcid.org/0009-0009-9986-8558)
- Youjun Chen (ORCID: https://orcid.org/0009-0004-8376-5101)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/phar.4603
- Citations
- 5
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Wannan Medical College