Inhibiting the NF-κB/DRP1 Axis Affords Neuroprotection after Spinal Cord Injury via Inhibiting Polarization of Pro-Inflammatory Microglia
We show that inhibition of the NF-κB/DRP1 axis prevents mitochondrial fission and suppresses pro-inflammatory microglia polarization, promoting neurological recovery in SCI. Targeting the NF-κB/DRP1 axis therefore represents a novel approach for SCI.
Authors
- Xiaoyong Zhao
- Baoshan Xu (ORCID: https://orcid.org/0000-0001-9595-0276)
- Song Chen (ORCID: https://orcid.org/0000-0001-6412-5740)
- Cheng Luo (ORCID: https://orcid.org/0009-0003-2405-1662)
- Kaihui Zhang (ORCID: https://orcid.org/0000-0003-4799-9133)
Institutions
- Second Hospital of Tangshan (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-08-23
- DOI
- https://doi.org/10.31083/j.fbl2908307
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49