Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure
Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.
Authors
- Julio A. Chirinos (ORCID: https://orcid.org/0000-0001-9035-5670)
- Ali Javaheri (ORCID: https://orcid.org/0000-0001-6657-331X)
- Oday Salman (ORCID: https://orcid.org/0000-0002-8390-1036)
- Bianca Pourmussa (ORCID: https://orcid.org/0000-0003-4763-795X)
- Marie‐Joe Dib (ORCID: https://orcid.org/0000-0001-7591-5684)
- Ernst R. Rietzschel (ORCID: https://orcid.org/0000-0002-8422-177X)
- Francisco Ramírez‐Valle (ORCID: https://orcid.org/0000-0002-8625-5869)
- Joe David Azzo (ORCID: https://orcid.org/0009-0000-8161-9611)
- Thomas P. Cappola (ORCID: https://orcid.org/0000-0002-9630-7204)
- Mark Richards (ORCID: https://orcid.org/0000-0002-2023-8177)
- Joseph Gogain (ORCID: https://orcid.org/0000-0001-7748-4822)
- Payman L. Zamani (ORCID: https://orcid.org/0000-0002-9345-5834)
- Leon Carayannopoulos
- Laura Liu (ORCID: https://orcid.org/0000-0002-3171-3172)
- David A. Gordon (ORCID: https://orcid.org/0000-0001-9882-8372)
- Douglas L. Mann (ORCID: https://orcid.org/0000-0002-2516-0145)
- Vanessa P. M. van Empel (ORCID: https://orcid.org/0000-0002-6864-0296)
- Christina Ebert (ORCID: https://orcid.org/0000-0003-0985-3547)
- Lei Zhao (ORCID: https://orcid.org/0000-0001-7099-3712)
- Zhaoqing Wang (ORCID: https://orcid.org/0000-0003-1515-4945)
- Peter H Schafer (ORCID: https://orcid.org/0000-0002-3880-0850)
- Danielle Greenawalt (ORCID: https://orcid.org/0000-0002-6297-0753)
- Ching‐Pin Chang (ORCID: https://orcid.org/0000-0001-8790-3445)
- Kushan L. Gunawardhana (ORCID: https://orcid.org/0009-0007-9432-9411)
- Manyun Zhao
- Sushrima Gan (ORCID: https://orcid.org/0000-0002-0221-9925)
Institutions
- Bristol-Myers Squibb (Germany) (DE)
- National University of Singapore (SG)
- Washington University in St. Louis (US)
- Hospital of the University of Pennsylvania (US)
- Ghent University Hospital (BE)
- Cardiovascular Institute Hospital (JP)
- Maastricht University (NL)
- Bristol-Myers Squibb (United States) (US)
- SomaLogic (United States) (US)
- National University Heart Centre Singapore (SG)
- University of Pennsylvania (US)
- University of Otago (NZ)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1161/jaha.123.033675
- Citations
- 14
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 4.57