The Ubiquitin E3 Ligase FBXO33 Suppresses Stem Cell-Like Properties and Metastasis in Non-Small-Cell Lung Cancer by Promoting Ubiquitination and Degradation of Myc
FBXO33 is expressed at low levels in NSCLC and correlates with lower OS. Overexpression of FBXO33 promotes Myc ubiquitination and degradation and inhibits tumor cell proliferation, migration and stemness characteristics, thereby impeding NSCLC progression.
Authors
- Qiong Wei (ORCID: https://orcid.org/0000-0001-5248-9678)
- Jing Zhu (ORCID: https://orcid.org/0000-0001-8893-9888)
- Haiqin Xie (ORCID: https://orcid.org/0000-0002-9109-1299)
- Keming Wang (ORCID: https://orcid.org/0000-0002-1358-3562)
- Ganzhu Feng (ORCID: https://orcid.org/0000-0001-9578-3834)
- Wenyan Jiang (ORCID: https://orcid.org/0009-0004-6647-605X)
- Zichun Liu
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Second Affiliated Hospital of Nantong University
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-08-21
- DOI
- https://doi.org/10.31083/j.fbl2908296
- Citations
- 5
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China