Elevated level of extracellular vimentin is associated with an increased fibrin formation potential in sepsis: ex vivo swine study
Thus, our swine model of sepsis-induced coagulopathy, reproduced increased extracellular circulating vimentin and subsequent potentiation of fibrin formation, often observed in septic patient. These outcomes validate the use of large animal models to investigate the dysregulated host immune response to infection leading to coagulopathy, and to develop new therapies for sepsis-induced disseminated microvascular thrombosis.
Authors
- Barbara J. Stoll (ORCID: https://orcid.org/0000-0003-4493-0851)
- Inka C. Didelija
- K. Vinod Vijayan
- Trung Nguyen (ORCID: https://orcid.org/0009-0007-6391-3113)
- Arun Saini (ORCID: https://orcid.org/0000-0001-7501-4720)
- Luis Gardea
- Miguel A. Crúz (ORCID: https://orcid.org/0000-0002-4417-0648)
- Marina Martinez-Vargas (ORCID: https://orcid.org/0000-0002-7119-8056)
- Subhashree Pradhan (ORCID: https://orcid.org/0009-0005-5216-5004)
Institutions
- Michael E. DeBakey VA Medical Center (US)
- Agricultural Research Service (US)
- United States Department of Agriculture (US)
- Baylor College of Medicine (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s40635-024-00660-5
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.38
Funders
- Fondren Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences