Synthesis of 1,1,3-Polyfunctionalized Cyclobutane Derivatives from the Reaction of Sulfur Ylides with Bicyclo[1.1.0]butanes
1,1,3-Polyfunctionalized cyclobutane derivatives have been synthesized from sulfur ylides and bicyclo[1.1.0]butanes (BCBs). This protocol operates under mild reaction conditions without the need for catalysts, generally producing moderate to good yields of <i>syn</i>-addition derivatives with structural diversity. An unexpected intramolecular rearrangement mechanism has also been proposed.
Authors
- Huajian Zhu (ORCID: https://orcid.org/0000-0002-6786-8811)
- Jiaan Shao (ORCID: https://orcid.org/0000-0001-8735-3236)
- Linghui Zeng (ORCID: https://orcid.org/0000-0002-3758-0366)
- Chong Zhang (ORCID: https://orcid.org/0000-0002-8113-5585)
- Chaowei Xiang
- Fang Luo (ORCID: https://orcid.org/0000-0002-2514-492X)
- Jiankang Zhang (ORCID: https://orcid.org/0000-0003-0365-7238)
- Ruoyu He (ORCID: https://orcid.org/0000-0001-5870-8560)
- Jing Wang
Institutions
- Hangzhou Xixi hospital (CN)
- Hangzhou City University
- Zhejiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c02388
- Citations
- 7
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Natural Science Foundation of Zhejiang Province