Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH
Classical swine fever (CSF) seriously restricts the healthy development of China's aquaculture industry, and the unclear pathogenic mechanism and pathogenesis of classical swine fever virus (CSFV) are the main obstacle to CSF prevention, control, and purification. Therefore, it is of great significance to explore the molecular mechanism of CSFV and host interplay, to search for the key signaling pathways and target molecules in the host that regulate the replication of CSFV infection, and to elucidate the mechanism of action of host immune dysfunction and immune escape due to CSFV infection for the development of novel CSFV vaccines and drugs. This study reveals the mechanism of serine metabolizing enzyme post-translational modifications and antiviral signaling proteins in the replication of CSFV and enriches the knowledge of CSFV infection and immune metabolism.
Authors
- Jindai Fan (ORCID: https://orcid.org/0000-0002-8454-1386)
- Bingke Li (ORCID: https://orcid.org/0000-0002-4324-6073)
- Linke Zou (ORCID: https://orcid.org/0009-0004-9540-0484)
- Zhaoyao Li
- Jinding Chen
- Yaoyao Huang (ORCID: https://orcid.org/0000-0002-7510-2410)
- Feifan Zhao (ORCID: https://orcid.org/0009-0008-3812-5067)
- Hongxing Ding (ORCID: https://orcid.org/0000-0001-9027-5662)
- Yuwei Qin
- Xinyan Wang (ORCID: https://orcid.org/0000-0002-5344-3281)
- Lihong Zhang (ORCID: https://orcid.org/0000-0003-2738-6268)
- Xiaowen Li (ORCID: https://orcid.org/0000-0001-9362-4274)
- Yi Lin
- Xueyi Liu (ORCID: https://orcid.org/0000-0002-6222-5825)
- Yiwan Song (ORCID: https://orcid.org/0000-0002-7222-3057)
- Mingqiu Zhao (ORCID: https://orcid.org/0000-0002-6960-9354)
- Wenxian Chen (ORCID: https://orcid.org/0000-0003-3986-7798)
- Shuangqi Fan (ORCID: https://orcid.org/0000-0003-4447-2395)
- Keke Wu (ORCID: https://orcid.org/0000-0001-5280-9862)
- Sen Zeng
- Yintao He
Institutions
- South China Agricultural University (CN)
Publication Details
- Journal
- mBio
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1128/mbio.02097-24
- Citations
- 11
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 6.24
Funders
- National Natural Science Foundation of China
- China Agricultural University
- South China Agricultural University