Critical roles of Dpb3-Dpb4 sub-complex of DNA polymerase epsilon in DNA replication, genome stability, and pathogenesis of <i>Candida albicans</i>
This study explored the role of DNA polymerase epsilon, especially its non-essential structural subunits in <i>Candida albicans</i> biology. Apart from their role in DNA replication and genome stability, the Dpb3-Dpb4 subcomplex regulates morphological switching and virulence. Since the defective strain is locked in filamentous form and is avirulent, the complex may be targeted for anti-fungal drug development.
Authors
- Abinash Dutta
- Bhabasha Gyanadeep Utkalaja
- Shraddheya Kumar Patel
- Narottam Acharya (ORCID: https://orcid.org/0000-0001-8858-5418)
- Satya Ranjan Sahu
Institutions
- Regional Centre for Biotechnology (IN)
- Institute of Life Sciences (IN)
Publication Details
- Journal
- mBio
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1128/mbio.01227-24
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Science and Engineering Research Board