Circulating Chemerin Levels in Obese and Non-obese Individuals and Its Association With Obesity in Metabolic Dysfunction-Associated Fatty Liver Disease

Introduction The prevalence of obesity and related disorders is rapidly rising due to altered food habits, sedentary lifestyles and stress. Adipose tissue releases various hormones known as adipokines; one example is chemerin, which is primarily expressed by hepatocytes, adipocytes, and immune cells. Adipokine dysregulation in obesity initiates the cascade of inflammation and insulin resistance that leads to various metabolic disorders such as diabetes mellitus, metabolic syndrome (MS), and metabolic dysfunction-associated fatty liver disease (MAFLD). Aim The aim of our research is to determine serum chemerin levels in obese and non-obese individuals and to estimate the prevalence of MAFLD in obesity. Materials and methods This cross-sectional study was conducted at SRM Medical College Hospital & Research Centre, Tamil Nadu from August 2023 to December 2023. The study group comprised 45 obese and 45 non-obese individuals above 18 years of age. New MAFLD diagnostic criteria and FLI (Fatty Liver Index) formula were used to stratify the cohort. The Godin Leisure-Time Exercise questionnaire was used to assess physical activity levels. Visceral fat was assessed using a body composition analyzer. Student's t-test and ANOVA were used to compare the difference in mean levels across the groups. Pearson's correlation was used to correlate the analyzed parameters. Results Among our obese study participants, nearly 50% reported following a sedentary lifestyle. The prevalence of MAFLD in our obese study group was 44% whereas the prevalence of non-alcoholic fatty disease was found to be only 33%. Fasting plasma glucose (FPG), HbA1c, triglycerides (TG) and chemerin levels were found to vary significantly between the two groups. However, our study did not reveal the association of chemerin with MAFLD, BMI, or visceral fat in obesity. A significant difference in BMI, and visceral fat was observed across groups stratified by their physical activity levels assessed using the Godin leisure questionnaire. Conclusion Our study highlights the effect of physical activity on adipose tissue distribution and metabolic health and does not reveal any significant association of chemerin with MAFLD, BMI, or visceral fat in obesity. Nearly half of the studied obese individuals lead sedentary lifestyles, which highlights the importance of promoting physical activity in the prevention of obesity and related metabolic dysfunction. To validate these findings, future research should involve larger, diverse cohorts and include longitudinal data to track shifts in chemerin levels over time and their impact on metabolic health.