Causal relationship between Interleukin-27 expression levels and osteoporosis: a bidirectional mendelian randomization study
This study supported that IL-27 level as a risk factor was causally connected with osteoporosis and might regulate the disease occurrence and progression by means of immune and inflammatory mechanisms, which could provide important reference and evidence for further exploring the role of IL-27 in the development of osteoporosis.
Authors
- You Zhou (ORCID: https://orcid.org/0000-0002-8660-5726)
- Rui Shi (ORCID: https://orcid.org/0000-0002-9374-0897)
- Jingshuang Zhang (ORCID: https://orcid.org/0000-0003-4716-7310)
- Chunyan Li (ORCID: https://orcid.org/0009-0008-6347-4517)
- Yun Xue
- Fei Liu (ORCID: https://orcid.org/0000-0002-9814-4226)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s12891-024-07765-8
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Beijing Municipal Health Commission
- Beijing Nova Program