Stereoselective Access to Spiro-isoindolinone Scaffolds via Catalytic Asymmetric aza-Piancatelli Rearrangement
A chiral Brønsted acid catalyzed asymmetric aza-Piancatelli rearrangement of 3-furyl-3-hydroxyisoindolinones with anilines has been developed, enabling the divergent construction of chiral spiro-cyclopentenone-isoindolinones in high yields with excellent diastereo- and enantioselectivities even under a low catalyst loading of 0.5 mol%.
Authors
- Yunfei Cai (ORCID: https://orcid.org/0000-0003-4823-8221)
- Yurong Tang (ORCID: https://orcid.org/0000-0002-4183-8008)
- Ling Yu (ORCID: https://orcid.org/0000-0002-0576-0557)
- Xukun Nie
Institutions
- Chongqing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c02799
- Citations
- 9
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Venture and Innovation Support Program for Chongqing Overseas Returnees