The Properties of the Transient Outward, Inward Rectifier and Acetylcholine-Sensitive Potassium Currents in Atrial Myocytes from Dogs in Sinus Rhythm and Experimentally Induced Atrial Fibrillation Dog Models
In our dog AF model, I<sub>to</sub> unlike in humans was downregulated only in a slight manner. Due to its slow inactivation kinetics, it seems that I<sub>to</sub> may play a more significant role in atrial repolarization than in ventricular working muscle myocytes. The presence of the constitutively active I<sub>K,ACh</sub> in atrial myocytes from AF dogs shows that electrical remodeling truly developed in this model. The I<sub>K,ACh</sub> current (both ligand-dependent and constitutively active) seems to play a significant role in canine atrial electrical remodeling and may be a promising atrial selective drug target for suppressing AF.
Authors
- András Varró
- László Sághy (ORCID: https://orcid.org/0000-0003-2917-0583)
- Claudia Corici
- István Baczkó (ORCID: https://orcid.org/0000-0002-9588-0797)
- Norbert Jost (ORCID: https://orcid.org/0000-0002-0838-2862)
- Zsófia Kohajda
- Attila Kristóf
- Zoltán Husti (ORCID: https://orcid.org/0000-0002-3956-8213)
- László Virág (ORCID: https://orcid.org/0000-0002-7099-6718)
Institutions
- University of Szeged (HU)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-08-29
- DOI
- https://doi.org/10.3390/ph17091138
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- European Commission
- Emberi Eroforrások Minisztériuma
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Szegedi Tudományegyetem