Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia
Lifetime head trauma may represent a preventable environmental risk factor for FTD/PPA. Dose-dependent exposure to TBI or RHI influences FTD/PPA symptom onset and memory function in bvFTD. Clinico-pathological studies are needed to better understand the neuropathological correlates linking RHI or TBI to FTD/PPA onset and symptoms.
Authors
- Lawren VandeVrede (ORCID: https://orcid.org/0000-0002-8304-6711)
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Breton M. Asken
- Howie Rosen
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Jeremy A. Tanner (ORCID: https://orcid.org/0000-0001-9828-1776)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Robert A. Stern (ORCID: https://orcid.org/0000-0002-5008-077X)
- Russell M. Bauer (ORCID: https://orcid.org/0000-0001-6807-2535)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Adam L. Boxer
- Jessica Bove
- Maria Luisa Gorno-Tempini
Institutions
- Boston University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- University of Florida Health (US)
- University of Florida (US)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s13195-024-01553-1
- Citations
- 6
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Larry L. Hillblom Foundation
- National Institute on Aging