Deficiency in Epithelium RAD50 Aggravates UC via IL-6-Mediated JAK1/2-STAT3 Signaling and Promotes Development of Colitis-Associated Cancer in Mice
RAD50 exerts anti-IL-6-related inflammatory effects in colitis and suppresses CAC. Increasing RAD50 level in colon tissues may be promising for treating patients with UC and CAC.
Authors
- Chaohui Yu (ORCID: https://orcid.org/0000-0003-4842-3646)
- Mengli Yu (ORCID: https://orcid.org/0000-0002-1368-1242)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-6673-0837)
- Songmin Ying (ORCID: https://orcid.org/0000-0002-1373-0438)
- Xin Song (ORCID: https://orcid.org/0000-0002-0569-6452)
- Tiantian Zhang (ORCID: https://orcid.org/0000-0001-7127-8593)
- Zhe Shen
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae134
- Citations
- 8
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province