Ball-Milling-Enabled Nickel-Catalyzed Reductive 1,4-Alkylarylation of 1,3-Enynes under an Air Atmosphere
A ball-mill-enabled nickel-catalyzed 1,4-alkylarylation of 1,3-enynes with organic bromides has been developed, offering a versatile method for assembling tetrasubstituted allenes. This approach, the first of ball-milling-based remote radical coupling, overcomes the limitations of traditional solution-phase methods, such as the need for air- and moisture-sensitive reagents, the use of bulk solvents, and prolonged reaction times. Given the outstanding performance of ball-milling-based radical reduction coupling reactions, we anticipate further advancements in sustainable and efficient synthetic methodologies.
Authors
- Yufang Yang (ORCID: https://orcid.org/0000-0001-9089-6020)
- Lei Hao (ORCID: https://orcid.org/0000-0003-2478-9723)
- Xiaofeng Wei (ORCID: https://orcid.org/0000-0002-5615-6712)
- Siyuan Wang (ORCID: https://orcid.org/0000-0002-8668-4057)
- Bobo Wang (ORCID: https://orcid.org/0000-0001-9777-4093)
- Shu Fan
Institutions
- Shenzhen University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shenzhen Technology University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c02729
- Citations
- 10
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.50
Funders
- Shenzhen Technology University
- Xi’an Jiaotong University
- Natural Science Foundation of Shaanxi Province