Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults
In this cohort study of cognitively unimpaired older adults with, at most, mild baseline depressive symptoms, greater depressive symptoms over time were associated with amyloid accumulation in regions associated with emotional control. Furthermore, these associations persisted in most regions independent of cognitive changes. These results shed light on the neurobiology of depressive symptoms in older individuals and underscore the importance of monitoring for elevated mood symptoms early in AD.
Authors
- Catherine E. Munro (ORCID: https://orcid.org/0000-0002-8707-1826)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Gad A. Marshall (ORCID: https://orcid.org/0000-0002-9096-2355)
- Patrizia Vannini (ORCID: https://orcid.org/0000-0002-9425-1059)
- Michelle Farrell (ORCID: https://orcid.org/0000-0002-5648-832X)
- Dorene M. Rentz (ORCID: https://orcid.org/0000-0002-6318-9213)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Michael J Properzi (ORCID: https://orcid.org/0000-0001-7855-2372)
- Ziwen Yuan (ORCID: https://orcid.org/0009-0003-5304-3450)
- Deborah Blacker
- Keith A. Johnson
- Reisa A. Sperling
Institutions
- Brigham and Women's Hospital (US)
- Michael E. DeBakey VA Medical Center (US)
- Cliniques Universitaires Saint-Luc (BE)
- Harvard University (US)
- Baylor College of Medicine (US)
- McLean Hospital (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- UCLouvain (BE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.27248
- Citations
- 11
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.59