Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell–expressed developmentally down-regulated gene 4-Like
NEDD4L, the E3 ubiquitination enzyme of ACE2, promotes the proliferation of PASMCs, ultimately leading to PAH.
Authors
- Tianya Liu (ORCID: https://orcid.org/0000-0002-5371-6497)
- Siqi Zhou (ORCID: https://orcid.org/0000-0002-0668-340X)
- Jingjing Dang
- Qianmin Chen
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-2127-1788)
- Zhiping Wang (ORCID: https://orcid.org/0000-0001-5217-0982)
- Rui Wang (ORCID: https://orcid.org/0009-0009-3413-940X)
- Rui Wang (ORCID: https://orcid.org/0009-0009-3413-940X)
Institutions
- Xuzhou Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
- Xuzhou Central Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s12931-024-02953-5
- Citations
- 5
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province