Evaluation of damage discrimination in dopaminergic neurons using dopamine transporter PET tracer [18F]FECNT-d4
Our findings demonstrate that [<sup>18</sup>F]FECNT-d<sub>4</sub> accurately estimates levels of dopaminergic neuron degeneration in the 6-OHDA-induced PD rat model and effectively distinguishes between PD patients and healthy individuals. This highly sensitive and safe PET probe holds promising potential for clinical application in the diagnosis and monitoring of Parkinson's disease.
Authors
- Yi Fang (ORCID: https://orcid.org/0000-0002-3547-5829)
- Congjin Liu
- Chunyi Liu (ORCID: https://orcid.org/0009-0005-7030-0310)
- Zhengping Chen (ORCID: https://orcid.org/0000-0003-1920-9464)
- Jie Tang (ORCID: https://orcid.org/0009-0006-3819-966X)
- Qianyue Hu
Institutions
- Fudan University (CN)
- Key Laboratory of Nuclear Radiation and Nuclear Energy Technology (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1186/s13550-024-01140-3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province