CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders
We detected a frequency of αSyn-SAA positivity in CBS and PSP in line with pathologic studies, highlighting the usefulness of SAAs for in vivo detection of otherwise undetectable neuropathologic processes. Our results also suggest that AD status (specifically low Aβ42) and older age at onset may contribute to αSyn-SAA positivity. This opens new perspectives for the stratification of patients in clinical trials.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- David F. Tang‐Wai (ORCID: https://orcid.org/0000-0001-9747-9967)
- Alonso Morales‐Rivero (ORCID: https://orcid.org/0000-0002-9015-4390)
- Gábor G. Kovács
- Ekaterina A. Rogaeva (ORCID: https://orcid.org/0000-0002-2852-0329)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Iván Martínez-Valbuena (ORCID: https://orcid.org/0000-0001-6463-6321)
- Foad Taghdiri (ORCID: https://orcid.org/0000-0002-3280-2804)
- Anna Vasilevskaya (ORCID: https://orcid.org/0000-0001-7398-9620)
- Susan H. Fox (ORCID: https://orcid.org/0000-0003-4779-4269)
- Simrika Thapa
- Chloe Anastassiadis (ORCID: https://orcid.org/0000-0002-0376-0422)
- Karen Misquitta (ORCID: https://orcid.org/0000-0002-5006-3005)
- Cassandra Jessica Anor
- Cristina Salvo
- Blas Couto (ORCID: https://orcid.org/0000-0002-3512-7488)
- Christine Sato (ORCID: https://orcid.org/0000-0001-7598-0996)
- Mohsen Hadian (ORCID: https://orcid.org/0000-0002-6789-0517)
- Daniela Mora‐Fisher
- D. González Moreno
Institutions
- Mahindra and Mahindra Limited (India) (IN)
Publication Details
- Journal
- Neurology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1212/wnl.0000000000209818
- Citations
- 20
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.38