Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation – A longitudinal population-based study
Prenatal exposure to lifestyle-related pro-inflammatory factors was the only prenatal predictor that accounted for some of the individual variability in MPS-CRP levels at birth. Further, while the MPS-CRP prospectively associated with white matter alterations over time, no associations were observed at the behavioral level. Thus, the relevance and potential utility of using epigenetic data as a marker of neonatal inflammation in the general population remain unclear. In the future, the use of epigenetic proxies for a wider range of immune markers may lend further insights into the relationship between neonatal inflammation and adverse neurodevelopment within the general pediatric population.
Authors
- Nicole Creasey (ORCID: https://orcid.org/0000-0002-1484-8593)
- Esther Walton (ORCID: https://orcid.org/0000-0002-0935-2200)
- Janine F. Felix (ORCID: https://orcid.org/0000-0002-9801-5774)
- Charlotte A. M. Cecil (ORCID: https://orcid.org/0000-0002-2389-5922)
- Liesbeth Duijts (ORCID: https://orcid.org/0000-0001-6731-9452)
- Anna Suleri (ORCID: https://orcid.org/0000-0003-4860-7277)
- Veerle Bergink (ORCID: https://orcid.org/0009-0003-4495-4762)
- Ryan L. Muetzel (ORCID: https://orcid.org/0000-0003-3215-1287)
Institutions
- Erasmus MC (NL)
- University College London (GB)
- University of Bath (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1016/j.bbi.2024.08.053
- Citations
- 6
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- Joint Programming Initiative A healthy diet for a healthy life
- Government of the United Kingdom
- UK Research and Innovation
- European Commission
- ZonMw
- Erasmus Universiteit Rotterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute of Mental Health
- H2020 European Research Council