Bio-effects of present of AL NPs in Different Vaccines on Hematology Analysis of Rabbit’s In-Vivo Study

In present study aims to measure the effects of different types vaccines (polio, and BCG) and aluminum nanoparticles (AL NPs) at different concentrations (0.5 and 1M) on eight hematological parameters: White blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGB), platelets (PLT), monocytes (MONO), granulocytes (GRANUL), hematocrit (HCT) and lymphocytes (LYMPHO). In the experimental twelve male rabbits in vivo non-randomized control trials were divided into four groups. Group control (n-6) and three groups injected with AL NPs (n-6) at different doses, BCG vaccine (n-6), and polio vaccine (n-6). The results after injected with AL NPs, BCG, and Polio vaccines with different doses and study the CBC analysis of all parameters are significant statistical analysis except for PLT values are non-significant. It seems from the results that the AL NPs has highly affected on the blood components and also, the both polio and BCG vaccines which have some percentage of nanoparticles of aluminum. The results of CBC analysis of blood mentioned the parameters analyzed are abnormal values that affected on the immune system of the animal. It can be concluded that the nanoparticles have been affected on the blood parameters, was long-duration more harmful and effect.