Cavity-Size-Adjustable Macrocycles as a Novel Vaccine Adjuvant for Tumor Immunotherapy

In this study, we constructed a macrocycle-based vaccine system driving antigen accumulation in lymph nodes. The capabilities of antigen delivery and immune activation as vaccine adjuvants are based on three positively charged water-soluble biphen[3]arenes (WP 3s: WTP3, WQP3, and WPP3) with different cavity sizes were synchronously investigated. Compared to the OVA group, WTP3, WQP3, and WPP3 exhibited a significant increase in the IgG antibody titer by ∼ 2.3 × 102-, 2.7 × 103-, and 7.6 × 103-fold, respectively. Therefore, we are convinced that biphen[3]arenes with larger cavity sizes not only demonstrate enhanced protein loading and binding capacity in vitro, but also manifest prolonged antigen retention time and heightened immune activation ability in vivo. To the best of our knowledge, this study represents the initial exploration of the impact of macrocyclic cavity sizes on the efficiency of antigen delivery as well as its potential influence on immune response capabilities.

Authors

Institutions

Publication Details

Journal
ACS Materials Letters
Published
2024-08-20
DOI
https://doi.org/10.1021/acsmaterialslett.4c00442
Citations
4
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.94

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Cavity-Size-Adjustable Macrocycles as a Novel Vaccine Adjuvant for Tumor Immunotherapy

Chunju Li, Yinyin Feng, Yuna Shang, Zhongyan Wang et al.
4 citations
ACS Materials Letters
RNA Interference and Gene Delivery
0.94
article

Cavity-Size-Adjustable Macrocycles as a Novel Vaccine Adjuvant for Tumor Immunotherapy

Chunju Li, Yinyin Feng, Yuna Shang, Zhongyan Wang, Hongjing Luo, Bin Li, Jiayu Wang, Fan Zhang, Chao Zhang, Ming Dong, Liu Hui, Junyi Chen, Aifeng Liu, Jiayi Lu
article en
4 citations

Abstract

In this study, we constructed a macrocycle-based vaccine system driving antigen accumulation in lymph nodes. The capabilities of antigen delivery and immune activation as vaccine adjuvants are based on three positively charged water-soluble biphen[3]arenes (WP 3s: WTP3, WQP3, and WPP3) with different cavity sizes were synchronously investigated. Compared to the OVA group, WTP3, WQP3, and WPP3 exhibited a significant increase in the IgG antibody titer by ∼ 2.3 × 102-, 2.7 × 103-, and 7.6 × 103-fold, respectively. Therefore, we are convinced that biphen[3]arenes with larger cavity sizes not only demonstrate enhanced protein loading and binding capacity in vitro, but also manifest prolonged antigen retention time and heightened immune activation ability in vivo. To the best of our knowledge, this study represents the initial exploration of the impact of macrocyclic cavity sizes on the efficiency of antigen delivery as well as its potential influence on immune response capabilities.

ACS Materials LettersVol. 6(9)
Tianjin Normal University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN), Henan Medical University (CN)
National Natural Science Foundation of China, Science and Technology Department of Henan Province
Openalex Percentile: Top 25%
RNA Interference and Gene Delivery
0.94
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.