Glaucoma detection with explainable AI using convolutional neural networks based feature extraction and machine learning classifiers

Abstract Glaucoma is an eye disease that damages the optic nerve as a result of vision loss, it is the leading cause of blindness worldwide. Due to the time‐consuming, inaccurate, and manual nature of traditional methods, automation in glaucoma detection is important. This paper proposes an explainable artificial intelligence (XAI) based model for automatic glaucoma detection using pre‐trained convolutional neural networks (PCNNs) and machine learning classifiers (MLCs). PCNNs are used as feature extractors to obtain deep features that can capture the important visual patterns and characteristics from fundus images. Using extracted features MLCs then classify glaucoma and healthy images. An empirical selection of the CNN and MLC parameters has been made in the performance evaluation. In this work, a total of 1,865 healthy and 1,590 glaucoma images from different fundus datasets were used. The results on the ACRIMA dataset show an accuracy, precision, and recall of 98.03%, 97.61%, and 99%, respectively. Explainable artificial intelligence aims to create a model to increase the user's trust in the model's decision‐making process in a transparent and interpretable manner. An assessment of image misclassification has been carried out to facilitate future investigations.