The role of inflammatory proteins in regulating the impact of lipid specifications on deep venous thrombosis: a two sample and mediated Mendelian randomization study
In our study, we identified CCL20 as a crucial mediator in the association between TAG(58:7) and DVT, with a mediating proportion of 12.51% (12%-13%). Further investigations are warranted to explore other potential risk factors acting as mediators.
Authors
- Yudong Zhang (ORCID: https://orcid.org/0000-0002-4870-1493)
- Fan Dong (ORCID: https://orcid.org/0000-0001-6730-0612)
- Jiahao Sun (ORCID: https://orcid.org/0000-0002-9475-3518)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-08-20
- DOI
- https://doi.org/10.3389/fcvm.2024.1434600
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75