Effects of Leydig cell elimination on testicular interstitial cell populations: characterization by scRNA-seq and immunocytochemical techniques
Seven interstitial cell types were identified and quantified for rat testis. Many may play more diversified roles than previously realized. The elimination of LCs led to significant changes in MCs and immune cells, indicating the importance of LCs in maintaining testicular interstitial homeostasis.
Authors
- Congde Chen (ORCID: https://orcid.org/0000-0001-9101-5678)
- Hu Wang (ORCID: https://orcid.org/0000-0002-4575-5699)
- Shuyan Cao
- Mengjie Qin (ORCID: https://orcid.org/0000-0001-8351-9083)
- Xiaoju Guan
- Yun Hu (ORCID: https://orcid.org/0000-0002-4477-3641)
- Jiexia Wang
- Haolin Chen (ORCID: https://orcid.org/0000-0001-7021-7115)
- Jingfeng Xu
- Ping Duan (ORCID: https://orcid.org/0000-0003-0177-182X)
- Zhenni Li (ORCID: https://orcid.org/0000-0003-1475-2265)
- Xin Wen (ORCID: https://orcid.org/0000-0002-3509-8496)
- Fu Huang
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.3389/fendo.2024.1423801
- Citations
- 2
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.07