Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer’s disease: a Mendelian randomization study
Our mediation MR analysis provides genetic evidence suggesting the potential mediating role of blood metabolites in the causal relationship between gut microbiota and AD. Further large-scale randomized controlled trials are warranted to validate the role of blood metabolites in the specific mechanisms by which gut microbiota influence AD.
Authors
- Cancan Chu
- Guanglei Chen (ORCID: https://orcid.org/0000-0002-8107-628X)
- Xing Feng Zhu (ORCID: https://orcid.org/0000-0003-0534-1712)
- Yunzhi Chen (ORCID: https://orcid.org/0000-0002-4546-5341)
- Yuhao Zheng (ORCID: https://orcid.org/0009-0008-1216-1684)
- Yaxian Jin
Institutions
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.3389/fmicb.2024.1414977
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.87