Unraveling the unphosphorylated STAT3–unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome
The reduced expression of downstream signaling molecules, specially <i>RANTES</i> and <i>STAT3</i>, confirmed the impaired uSTAT3-uNF-κB pathway in STAT3 LOF HIES. Decreased levels of RANTES and STAT3 could be a significant component in the disease pathogenesis of Hyper IgE Syndrome.
Authors
- Biman Saikia (ORCID: https://orcid.org/0000-0001-7181-6064)
- Surjit Singh (ORCID: https://orcid.org/0000-0002-8990-3235)
- Smrity Sahu (ORCID: https://orcid.org/0000-0002-9848-591X)
- Adil Karim (ORCID: https://orcid.org/0000-0001-6707-1725)
- Ranjana W. Minz
- Amit Rawat (ORCID: https://orcid.org/0000-0002-5875-2892)
- Rashi Garg (ORCID: https://orcid.org/0000-0001-6615-5353)
- Deepti Suri
- Abha Tiwari
- Mehak Malhotra
Institutions
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1332817
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jeffrey Modell Foundation