Serum Magnesium and Glycemic Status in Newly Diagnosed T2DM Patients in Tertiary Care Hospital of Bangladesh

Background: Diabetes mellitus is a major global health issue. Trace elements play important role as co-factors for various events in this context. Recently, an inverse relationship between serum magnesium and glycemic control has been observed and magnesium is thought to be low in with type-2 diabetes mellitus (T2DM). Objective: This study aimed to see serum magnesium and HbA1c in newly diagnosed T2DM. Methodology: This cross-sectional study included 100 newly detected diabetes subjects (age: 40.65±11.65 years, mean ± SD; m/f: 35/65) diagnosed according to American Diabetic Association (ADA) 2016 diagnostic criteria for diabetes. 5 ml of blood was collected for serum magnesium and HbA1c measurement by utilizing atomic absorption Spectrometricanalysis and NGSP certified Bio-Rad D-10TM Hemoglobin A1c Program 220-0101 USA. All data were analyzed by SPSS (version 22.0). Results: Magnesium and HbA1c were 1.99±0.23 mg/dl and 8.65±2.18% (mean±SD). About 9% were hypomagnesemic and 91% eumagnesemic. Socioeconomically 50% were middle income group, family history was present in 48% and 11% had history of smoking. Magnesium (meanSD) was statistically similar between males and females (1.99±0.22 vs. 1.99±0.24 mg/dl, p=0.974), urban and rural subjects (1.98±0.24 vs. 1.99±0.22 mg/dl, p=0.754), subjects with or without family history of diabetes (1.95±0.22 vs. 2.02±0.23 mg/dl, p=0.117), in subjects with BMI <25 Kg/m2 and 25 Kg/m2 (2.01±0.25 vs. 1.98±0.22 mg/dl, p= 0.526) as well as among various HbA1c cut-off values (<6.5 vs. 6.5− 9 vs. >9%: 2.08 ±0.15 vs. 1.98±0.24 vs. 1.99±0.23; p=0.257). However, magnesium level was statistically and significantly different among the age groups (<25 yrs vs. 25-34 yrs vs. 35-44 yrs vs. 45-54 yrs vs. 55 yrs: 1.91±0.28 vs. 2.00±0.23 vs. 1.93±0.20 vs. 1.96±0.26 vs. 2.16±0.13 mg/dl, meanSD; p= 0.018). None of the variables showed any correlation with magnesium except age (r=0.220, p=0.028) nor any was significant independent predictor for hypomag