Efficacy and Safety of Artemether-Lumefantrine Against Uncomplicated Falciparum Malaria Infection in Tanzania, 2022: A Single-Arm Clinical Trial
Artemether-lumefantrine remains highly efficacious in 3 regions of Tanzania, but the PCR-corrected efficacy in Pwani fell below the WHO-defined 90% threshold at which policy change is recommended. Implementing strategies to diversify artemisinin-based combination therapies to ensure effective case management in Tanzania is critical.
Authors
- Filbert Francis (ORCID: https://orcid.org/0000-0003-1000-4729)
- Muhidin K. Mahende (ORCID: https://orcid.org/0000-0003-4923-9023)
- Marian Warsame (ORCID: https://orcid.org/0000-0002-7469-977X)
- Jovin Kitau (ORCID: https://orcid.org/0000-0002-8115-8031)
- Florida Muro (ORCID: https://orcid.org/0000-0002-5127-3995)
- Erasmus Kamugisha (ORCID: https://orcid.org/0000-0002-7285-6313)
- Kefas Mugittu
- Dunstan R. Bishanga (ORCID: https://orcid.org/0000-0001-5970-6604)
- Billy Ngasala (ORCID: https://orcid.org/0000-0001-9300-7719)
- Marko Bajic (ORCID: https://orcid.org/0000-0002-8566-5153)
- Deus S. Ishengoma (ORCID: https://orcid.org/0000-0003-2040-3416)
- Reginald Adolph Kavishe (ORCID: https://orcid.org/0000-0001-9147-5295)
- Bilali Kabula (ORCID: https://orcid.org/0000-0002-7374-169X)
- Frank Chacky (ORCID: https://orcid.org/0000-0002-6521-9156)
- Naomi Serbantez (ORCID: https://orcid.org/0000-0003-0204-7796)
- Sixbert I. Mkumbaye (ORCID: https://orcid.org/0000-0001-8541-3848)
- Mercy G. Chiduo (ORCID: https://orcid.org/0000-0002-2126-9039)
- Jessica Laury (ORCID: https://orcid.org/0000-0003-4578-0488)
- Celine I. Mandara (ORCID: https://orcid.org/0000-0003-4317-4425)
- Maimuna Ahmed
- Erik J. Reaves (ORCID: https://orcid.org/0000-0001-9822-5010)
- Debora Charles Kajeguka (ORCID: https://orcid.org/0000-0003-4341-5938)
- Chonge Kitojo
Institutions
- Ifakara Health Institute (TZ)
- Centers for Disease Control and Prevention (US)
- World Health Organization - Pakistan (PK)
- Muhimbili University of Health and Allied Sciences (TZ)
- RTI International (US)
- African Malaria Network Trust (TZ)
- Catholic University of Health and Allied Sciences (TZ)
- Eckernforde Tanga University (TZ)
- U.S. President's Malaria Initiative (US)
- Public Health Institute (US)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- Kilimanjaro Christian Medical Centre (TZ)
- Bugando Medical Centre (TZ)
- Nordic School of Public Health (SE)
- Division of Parasitic Diseases and Malaria (US)
- National Institute for Medical Research (TZ)
- University of Gothenburg (SE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1093/infdis/jiae425
- Citations
- 7
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.80