Mutual Amplification of <scp>GLI2</scp>/Hedgehog and Transcription Factor <scp>JUN</scp>/<scp>AP</scp>‐1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies
The transcription factors cJUN and GLI2 reinforce each other's activity to promote fibroblast activation in SSc. Interruption of this crosstalk by combined inhibition of both pathways exerts additive antifibrotic effects at well-tolerated doses.
Authors
- Chunguang Liang (ORCID: https://orcid.org/0000-0002-0305-2522)
- Nicholas Dickel (ORCID: https://orcid.org/0000-0002-5397-7662)
- Christina Bergmann (ORCID: https://orcid.org/0000-0001-5257-9171)
- Sara Chenguiti Fakhouri
- Jörg H. W. Distler (ORCID: https://orcid.org/0000-0001-7408-9333)
- Clara Dees (ORCID: https://orcid.org/0000-0001-5443-0602)
- Janina Auth (ORCID: https://orcid.org/0000-0002-5142-2620)
- Benita Merlevede
- Arif B. Ekici (ORCID: https://orcid.org/0000-0001-6099-7066)
- Ludwig Hallenberger
- Xiang Zhou
- Simon Rauber (ORCID: https://orcid.org/0000-0001-8306-9334)
- Aline Bözec (ORCID: https://orcid.org/0000-0001-8174-2118)
- Alexandru‐Emil Matei (ORCID: https://orcid.org/0000-0003-1248-3145)
- Georg Andreas Schett (ORCID: https://orcid.org/0000-0001-8740-9615)
- Andrea‐Hermina Györfi (ORCID: https://orcid.org/0000-0002-4960-3369)
- Aleix Rius Rigau (ORCID: https://orcid.org/0000-0002-0871-306X)
- Meik Kunz (ORCID: https://orcid.org/0000-0003-0385-2084)
- Tim Filla (ORCID: https://orcid.org/0000-0001-5628-8398)
- Honglin Zhu (ORCID: https://orcid.org/0000-0001-8724-2835)
- Trinh‐Minh Thuong
Institutions
- Central South University (CN)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- Xiangya Hospital Central South University (CN)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1002/art.42979
- Citations
- 12
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Research Committee, Aristotle University of Thessaloniki