Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading
Histological grading is the key factors affecting the prognosis and instructive in guiding treatment and assessing recurrence in non-functional pancreatic neuroendocrine tumor (NF-Pan-NET). Approximately one-third of patients without copy number variation (CNV) alteration and the prognosis of these patients are better than that of patients with CNV alteration. However, the difference between CNV and histological grading is unclear. Here, we analyzed the heterogeneity of tumor cells according to two classification criteria, genomic instability (including CNV alteration and tumor mutation burden) and histological grading. We revealed that the activated core pathways of tumor cells were significantly different under different histological grading's and genomic instability patterns. We also found that tip cells, lymphatic endothelial cells, macrophages, <i>CD1A</i> + dendritic cell, Treg, MAIT, ILC, and CAFs might participate in the process of hepatic metastases, which will facilitate the understanding of the patterns to decode the malignant potential and of NF-Pan-NET.
Authors
- Shunrong Ji (ORCID: https://orcid.org/0000-0003-2556-3320)
- Yuheng Hu (ORCID: https://orcid.org/0000-0003-4551-506X)
- Qingtong Zhou (ORCID: https://orcid.org/0000-0001-8124-3079)
- Jie Chen (ORCID: https://orcid.org/0009-0002-1536-2007)
- Ye Zeng (ORCID: https://orcid.org/0000-0001-5440-6194)
- Xin Lou (ORCID: https://orcid.org/0000-0002-6715-0375)
- Di Zhu (ORCID: https://orcid.org/0000-0002-9362-3834)
- Yan Zhou (ORCID: https://orcid.org/0000-0002-9205-9936)
- Zijin Xu (ORCID: https://orcid.org/0000-0001-7230-0131)
- Yi Qin (ORCID: https://orcid.org/0000-0001-9804-202X)
- Wuhu Zhang (ORCID: https://orcid.org/0000-0002-5182-9850)
- Qiang Li (ORCID: https://orcid.org/0000-0001-6732-4083)
- Cao Xie
- Xiaowu Xu (ORCID: https://orcid.org/0000-0001-5792-9839)
- Ming‐Wei Wang (ORCID: https://orcid.org/0000-0001-6550-9017)
- Hu Zhou (ORCID: https://orcid.org/0009-0000-0381-3849)
- Dehua Yang
- Xianjun Yu
- Jing Gao (ORCID: https://orcid.org/0000-0002-2131-7301)
Institutions
- Tongji University (CN)
- Shanghai Medical College of Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
- Zhongshan Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Institute of Deep-Sea Science and Engineering (CN)
- The University of Tokyo (JP)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- iScience
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1016/j.isci.2024.110836
- Citations
- 13
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Municipal Education Commission
- Science and Technology Commission of Shanghai Municipality
- Shanghai Hospital Development Center
- National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology