A severe asthma phenotype of excessive airway <i>Haemophilus influenzae</i> relative abundance associated with sputum neutrophilia
We describe a Haemophilus influenzae cluster of the highest relative abundance associated with neutrophilic inflammation and NETosis indicating a host response to the bacteria. This phenotype of severe asthma may respond to specific antibiotics.
Authors
- Fransiskus Xaverius Ivan (ORCID: https://orcid.org/0000-0001-6491-6358)
- Mahmoud I. Abdel‐Aziz (ORCID: https://orcid.org/0000-0001-9263-7137)
- Adnan Azim (ORCID: https://orcid.org/0000-0001-5960-1159)
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Ali Versi
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Anke-H. Maitland-Van Der Zee
- Nazanin Zounemat Kermani (ORCID: https://orcid.org/0000-0003-2479-3861)
- Sanjay H. Chotirmall (ORCID: https://orcid.org/0000-0003-0417-7607)
- Ian Michael Adcock (ORCID: https://orcid.org/0000-0003-2101-8843)
- Mohib Uddin (ORCID: https://orcid.org/0000-0002-2412-2657)
- Peter Howarth (ORCID: https://orcid.org/0000-0003-0619-7927)
- Sven‐Eric Dahlen
- John Riley
- Stewart Bates
Institutions
- Nanyang Technological University (SG)
- Frimley Park Hospital (GB)
- Tan Tock Seng Hospital (SG)
- Karolinska Institutet (SE)
- AstraZeneca (Sweden) (SE)
- Amsterdam University Medical Centers (NL)
- University of Southampton (GB)
- Imperial College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1002/ctm2.70007
- Citations
- 12
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- European Federation of Pharmaceutical Industries and Associations
- UK Research and Innovation
- European Commission
- Innovative Medicines Initiative
- Biotechnology and Biological Sciences Research Council
- Seventh Framework Programme