Apurinic/apyrimidinic endonuclease 1 alleviates inflammation in fibroblast-like synoviocytes from patients with rheumatoid arthritis
These findings collectively underscore the role of APEX1 as a key mediator of cytokine-amplified migration, modulating ROS and MMP3 in RA FLS, thus supporting its potential as a therapeutic target in RA treatment.
Authors
- Seong Wook Kang (ORCID: https://orcid.org/0000-0002-0076-0822)
- Ha‐Reum Lee (ORCID: https://orcid.org/0000-0001-9200-4372)
- Byeong Hwa Jeon (ORCID: https://orcid.org/0000-0002-3347-2739)
- Hee Kyoung Joo
- Jinhyun Kim (ORCID: https://orcid.org/0000-0001-5235-2612)
- Su-Jin Yoo
- Yu Ran Lee
Institutions
- Chungnam National University (KR)
- Chungnam National University Hospital (KR)
Publication Details
- Journal
- Central European Journal of Immunology
- Published
- 2024-08-26
- DOI
- https://doi.org/10.5114/ceji.2024.141946
- Citations
- 1
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- National Research Foundation
- Chungnam National University
- National Research Foundation of Korea
- Chungnam National University Hospital