Upregulation of Mitochondrial Sirt3 and Alleviation of the Inflammatory Phenotype in Macrophages by Estrogen
The study suggests that E2 treatment upregulates Sirt3 expression in macrophages. In primary BMMs, female-specific Sirt3 upregulation was observed. The Sirt3 upregulation was accompanied by mitochondrial protein deacetylation and the alleviation of the oxidative and pro-inflammatory phenotype in M1 macrophages. Thus, the E2-Sirt3 axis might be used in a therapeutic strategy to fight chronic systemic inflammation and prevent the development of inflammation-linked diseases.
Authors
- Natalie Haritonow
- Muhammad Aslam (ORCID: https://orcid.org/0000-0002-8529-4217)
- Maria Luisa Barcena (ORCID: https://orcid.org/0000-0003-1391-9262)
- Yury Ladilov (ORCID: https://orcid.org/0000-0002-9836-8801)
- Vera Regitz‐Zagrosek (ORCID: https://orcid.org/0000-0002-3566-3467)
- Céline Christiansen-Mensch
Institutions
- Justus-Liebig-Universität Gießen (DE)
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- German Centre for Cardiovascular Research (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cells
- Published
- 2024-08-25
- DOI
- https://doi.org/10.3390/cells13171420
- Citations
- 16
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Bundesministerium für Bildung und Forschung