Free Cortisol and Free 21-Deoxycortisol in the Clinical Evaluation of Congenital Adrenal Hyperplasia
Free cortisol concentrations in patients with classic CAH were similar to those in controls and patients with NCCAH, indicating comparable cortisol availability. Additionally, patients with 21OHD produce high concentrations of 21DF, possibly explaining the low occurrence of symptoms in some patients with classic 21OHD. Free cortisol and 21DF levels should be considered in evaluating adrenal insufficiency in patients with CAH.
Authors
- Bas P H Adriaansen (ORCID: https://orcid.org/0000-0003-1439-236X)
- Antonius Eduard van Herwaarden (ORCID: https://orcid.org/0000-0002-5417-8272)
- André J. Olthaar (ORCID: https://orcid.org/0000-0002-0143-2767)
- Karijn J. Pijnenburg-Kleizen (ORCID: https://orcid.org/0000-0001-7040-4973)
- Agustini Utari (ORCID: https://orcid.org/0000-0001-5965-1981)
- Fred C.G.J. Sweep (ORCID: https://orcid.org/0000-0003-1103-3070)
- Hedi L. Claahsen‐van der Grinten (ORCID: https://orcid.org/0000-0003-0181-0403)
- Paul N. Span (ORCID: https://orcid.org/0000-0002-1930-6638)
- Rob C.B.M. van der Steen
- Lizanne Berkenbosch
Institutions
- Diponegoro University (ID)
- Radboud University Nijmegen (NL)
- Maastricht University Medical Centre (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Amalia Kinderziekenhuis (NL)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-08-25
- DOI
- https://doi.org/10.1210/clinem/dgae591
- Citations
- 5
- Primary Topic
- Sexual Differentiation and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.17