Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma
Gut microbiota-derived metabolites were differentially abundant in patients with HCC versus healthy controls. The observed perturbations of the TMAO pathway in HCC seem particularly promising as a target of future research and may have both diagnostic and therapeutic implications.
Authors
- Justin Durla Lathia (ORCID: https://orcid.org/0000-0003-3168-7290)
- Jennifer Wilcox (ORCID: https://orcid.org/0000-0001-6277-1079)
- Courtney E. Hershberger (ORCID: https://orcid.org/0000-0002-2195-989X)
- Jennifer S. Yu
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Zeneng Wang (ORCID: https://orcid.org/0000-0002-6455-8228)
- Chase J. Wehrle (ORCID: https://orcid.org/0000-0002-9275-4744)
- Federico Aucejo (ORCID: https://orcid.org/0000-0001-7841-229X)
- J. Mark Brown (ORCID: https://orcid.org/0000-0003-2708-7487)
- Daniel Miller Rotroff (ORCID: https://orcid.org/0000-0003-0553-3220)
- Marko Mrdjen (ORCID: https://orcid.org/0000-0003-3000-0266)
- Vinayak Uppin
- Rakhee Banerjee (ORCID: https://orcid.org/0000-0002-2299-7177)
- Ofer Reizes (ORCID: https://orcid.org/0000-0003-0075-6871)
- Venkateshwari Varadharajan (ORCID: https://orcid.org/0000-0002-4557-9840)
- Stanley L. Hazen
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-08-26
- DOI
- https://doi.org/10.3390/biomedicines12091946
- Citations
- 14
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.41