Ovariectomy exacerbates the disturbance of excitation- inhibition balance in the brain of APP/PS-1/tau mice
Our results suggested that OVX-induced estrogen-estrogen receptors pathway disruption caused learning and memory impairment and anxiety and depression-like behaviors, upregulated the expression of AD pathological markers, promoted apoptosis, destroyed neuronal structure, and most importantly, caused glutamatergic/GABAergic nervous system disorders.
Authors
- Xu-Ri Shen
- Jiarui Du
- Yanman Liu (ORCID: https://orcid.org/0009-0008-7169-0877)
- Xueqin Hou (ORCID: https://orcid.org/0000-0001-7075-3321)
- Fu-Wang Liu (ORCID: https://orcid.org/0009-0009-2684-0634)
- Hanting Zhang (ORCID: https://orcid.org/0000-0002-4208-3786)
Institutions
- Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-08-26
- DOI
- https://doi.org/10.3389/fnmol.2024.1391082
- Citations
- 3
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.07