Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides

Researchers are paying increasing attention to the strongly negatively charged heteropolysaccharides in cells, in the extracellular matrix or in the cell wall. Examples of such molecules are glycosaminoglycans (e.g., heparin, heparan sulphate). It is well known from the literature that heparin and its derivatives have anti-inflammatory, angiogenic, metastatic and growth factor inhibitory activity. Herein, we present the efficient synthesis of six non-glycosaminoglycan (Glc-GlcA-Glc-sequenced) and one heparin-related (GlcN-GlcA-Glc-sequenced) trisaccharides with various functional group patterns. The anti-inflammatory, antioxidant and cell growth-inhibitory/cytotoxic effects of the synthesized compounds were tested. Among the investigated molecules, we have found some derivatives with a promising anti-inflammatory and antioxidant effect.

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Publication Details

Journal
Biomolecules
Published
2024-08-25
DOI
https://doi.org/10.3390/biom14091052
Citations
6
Primary Topic
Proteoglycans and glycosaminoglycans research
Type
article
Field-Weighted Citation Impact
1.96

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article

Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides

Ágnes Rusznyák, Anikó Borbás, Attila Gábor Szöllősi, István Lekli et al.
6 citations
Biomolecules
Proteoglycans and glycosaminoglycans research
1.96
article

Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides

Ágnes Rusznyák, Anikó Borbás, Attila Gábor Szöllősi, István Lekli, Petra Molnár, Mihály Herczeg, Fruzsina Demeter, Ferenc Fenyvesi, Erika Lisztes, Richárd Kajtár, Balázs István Tóth, Éva Sipos, Katalin Kútvölgyi, Zsófia Peleskei
article en
6 citations

Abstract

Researchers are paying increasing attention to the strongly negatively charged heteropolysaccharides in cells, in the extracellular matrix or in the cell wall. Examples of such molecules are glycosaminoglycans (e.g., heparin, heparan sulphate). It is well known from the literature that heparin and its derivatives have anti-inflammatory, angiogenic, metastatic and growth factor inhibitory activity. Herein, we present the efficient synthesis of six non-glycosaminoglycan (Glc-GlcA-Glc-sequenced) and one heparin-related (GlcN-GlcA-Glc-sequenced) trisaccharides with various functional group patterns. The anti-inflammatory, antioxidant and cell growth-inhibitory/cytotoxic effects of the synthesized compounds were tested. Among the investigated molecules, we have found some derivatives with a promising anti-inflammatory and antioxidant effect.

BiomoleculesVol. 14(9)
University of Debrecen (HU), University of Pecs (HU)
Debreceni Egyetem, Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
Openalex Percentile: Top 15%
Proteoglycans and glycosaminoglycans research
1.96
DOIOpen Access PDFOpenAlex
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