Prediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma
In this work, broadband diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) were used to quantify deep tissue hemodynamics in a patient-derived orthotopic xenograft mouse model of clear cell renal cancer undergoing antiangiogenic treatment. A cohort of twenty-two mice were treated with sunitinib and compared to thirteen control untreated mice, and monitored by DRS/DCS. A reduction in total hemoglobin concentration (THC, p = 0.03), oxygen saturation (SO<sub>2,</sub> p = 0.03) and blood flow index (BFI, p = 0.02) was observed over the treatment course. Early changes in tumor microvascular blood flow and total hemoglobin concentration were correlated with the final microvessel density (p = 0.014) and tumor weight (p = 0.024), respectively. Higher pre-treatment tumor microvascular blood flow was observed in non-responder mice with respect to responder mice, which was statistically predictive of the tumor intrinsic resistance (p = 0.01). This hybrid diffuse optical technique provides a method for predicting tumor intrinsic resistance to antiangiogenic therapy and could be used as predictive biomarker of response to antiangiogenic therapies in pre-clinical models.
Authors
- David R. Busch (ORCID: https://orcid.org/0000-0002-9488-944X)
- Turgut Durduran (ORCID: https://orcid.org/0000-0001-5838-1027)
- Oriol Casanovas (ORCID: https://orcid.org/0000-0002-4298-3995)
- Ernesto E. Vidal-Rosas (ORCID: https://orcid.org/0000-0002-4486-7592)
- Jordi Morales-Dalmau (ORCID: https://orcid.org/0000-0002-4867-7032)
- Clara Vilches (ORCID: https://orcid.org/0000-0002-2695-2128)
- Gabriela Jiménez-Valerio
- Johannes Johansson (ORCID: https://orcid.org/0000-0003-4910-0291)
- Miguel Mireles (ORCID: https://orcid.org/0000-0002-6579-3844)
- Valentí Navarro-Pérez
- Mar Martínez-Lozano
Institutions
- Linköping University (SE)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Northeastern University (US)
- Institute of Photonic Sciences (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Institut Català d'Oncologia (ES)
- University of Southampton (GB)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Universidad del Noreste (MX)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1364/boe.532052
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Cellex
- “la Caixa” Foundation
- Ministerio de Ciencia, Innovación y Universidades
- Centres de Recerca de Catalunya
- Laserlab-Europe
- Generalitat de Catalunya
- Consejo Nacional de Ciencia y Tecnología
- Ministerio de Economía y Competitividad
- FUNDACIÓ Privada MIR-PUIG
- Horizon 2020 Framework Programme
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- H2020 Research Infrastructures
- FP7 Ideas: European Research Council