Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration
After myocardial infarction, decreased sirtuin activity enriches YAP acetylation at K265. The growing TUBA4A network sequesters acetylated YAP within the cytoplasm, which is detrimental to cardiac regeneration.
Authors
- Yidan Wang (ORCID: https://orcid.org/0000-0002-0741-6506)
- Jeffrey D. Steimle (ORCID: https://orcid.org/0000-0002-1369-9661)
- Vaibhav Deshmukh (ORCID: https://orcid.org/0000-0002-0087-7545)
- Yuka Morikawa (ORCID: https://orcid.org/0000-0002-4571-8409)
- James F. Martin (ORCID: https://orcid.org/0000-0002-7842-9857)
- Shijie Liu (ORCID: https://orcid.org/0000-0002-2597-5416)
- Gang Li (ORCID: https://orcid.org/0000-0001-9661-8304)
- Fansen Meng (ORCID: https://orcid.org/0000-0003-3173-5512)
- Jun Wang (ORCID: https://orcid.org/0000-0003-1576-6909)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Valve (United States) (US)
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-08-26
- DOI
- https://doi.org/10.1161/circulationaha.123.067646
- Citations
- 19
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 6.19
Funders
- Cincinnati Children's Hospital Medical Center
- Rice University